Study overview
A study combining in-vitro pharmaceutical tests, a Caco-2 cell model and an osteoporotic mouse model showed higher in-vitro dissolution, improved vitamin D3 stability and higher calcium transport; some bone indices and trabecular micro-structure improved, with lower observed stone-related risk. The paper explicitly describes complexation and inclusion technologies.
- Research focus
- Formulation properties and bone metabolism in cell and animal models
- Study design
- Pharmaceutical experiments, Caco-2 cells and an osteoporotic mouse model
- Study population
- Cell and animal experiments
- Publication / contributor
- Journal of Food Biochemistry
Main findings
| Measure | Result | Context |
|---|---|---|
| In-vitro dissolution | Higher | |
| Vitamin D3 stability | Improved | |
| Caco-2 calcium transport | Higher | |
| Mouse trabecular microarchitecture | Improvement in some measures | Micro-CT observations |
| Stone-related risk measures | Lower in the CCCG group | Animal model |
Results and interpretation
The study examined compound calcium carbonate granules through formulation tests, cell experiments and animal models. Assessments included calcium release, vitamin D3 stability, Caco-2 transport, and bone tissue and metabolism measures in osteoporotic mice.
Reported differences in dissolution, stability, cellular transport and selected mouse bone measures provide experimental evidence on complexation and inclusion technology.
Study notes
This is formulation and preclinical research, with observations tied to specific experimental conditions. Cellular transport and animal bone measures are distinct from human absorption and fracture outcomes.
Stone-related observations are limited to the animal model and observation period described in the paper.
References
Efficacy for Bone Deterioration in Mice with Osteoporosis and Pharmaceutical Properties of a Novel Compound Calcium Carbonate Granule. Journal of Food Biochemistry, 2023.
- Ma et al. Mouse osteoporosis and formulation study (2023), abstract and bibliographic record in OpenAlexBibliographic record with abstract
